Enalapril, a angiotensin converting enzyme(ACE) inhibitor, was given in a single oral dose of 10mg to 13 patients with essential hypertension and to 10 control patients with normal blood pressure. Blood pressure, plasma renin activity,
aldosteron,
and
ACE activity were measured before and after enalapril administration.
@ES The results were as follows:
@EN 1. At 3hours. After administration of enalapril, plasma ACE activity decreased in both groups of patients(p<0.05) but more decreased in patients with essential hypertension from 19.4±8.8 to 9.7±5.7 nmole/min/ml(p<0.05).
2. Decreased levels of plasma ACE activity were accompanied by reduction of blood pressure in response to enalapril, especially systolic blood pressure in patients with essential hypertension. Blood pressure also decreased in both groups of
patients
including those with normal or low renin levels(p<0.05), but there was not a significant correlation between the magnitude of blood pressure reduction and baseline plasma renin activity.
3. After 10 mg of enalapril administration, mean plasma renin activity rose(p<0.05), while plasma aldosterone concentration fell in both grousp of patients.
It suggest that enalapril is an effective ACE inhibitor and the measurement of plasma ACE activity is useful for monitoring the efficacy of ACE inhibitor and compliance to treatment with enalapril.
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